CD79a promotes CNS-infiltration and leukemia engraftment in pediatric B-cell precursor acute lymphoblastic leukemia
نویسندگان
چکیده
Abstract Central nervous system (CNS) involvement remains a challenge in the diagnosis and treatment of acute lymphoblastic leukemia (ALL). In this study, we identify CD79a (also known as Ig?), signaling component preB cell receptor (preBCR), to be associated with CNS-infiltration –relapse B-cell precursor (BCP)-ALL patients. Furthermore, show that downregulation hampers engraftment cells different murine xenograft models, particularly CNS.
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ژورنال
عنوان ژورنال: Communications biology
سال: 2021
ISSN: ['2399-3642']
DOI: https://doi.org/10.1038/s42003-020-01591-z